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Structural basis for σ(1) receptor ligand recognition

The σ(1) receptor is a poorly understood membrane protein expressed throughout the human body. Ligands targeting the σ(1) receptor are in clinical trials for treatment of Alzheimer’s disease, ischemic stroke, and neuropathic pain. Despite this, relatively little is known regarding the σ(1) receptor’...

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Pubblicato in:Nat Struct Mol Biol
Autori principali: Schmidt, Hayden R., Betz, Robin M., Dror, Ron O., Kruse, Andrew C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6261271/
https://ncbi.nlm.nih.gov/pubmed/30291362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-018-0137-2
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