Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5

The chemokine receptor CCR5 plays a vital role in immune surveillance and inflammation. However, molecular details that govern its endogenous chemokine recognition and receptor activation remain elusive. Here we report three cryo-electron microscopy structures of G(i1) protein-coupled CCR5 in a liga...

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Vydáno v:Nat Commun
Hlavní autoři: Zhang, Hui, Chen, Kun, Tan, Qiuxiang, Shao, Qiang, Han, Shuo, Zhang, Chenhui, Yi, Cuiying, Chu, Xiaojing, Zhu, Ya, Xu, Yechun, Zhao, Qiang, Wu, Beili
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8260604/
https://ncbi.nlm.nih.gov/pubmed/34230484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24438-5
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