Structure of the CCR5 chemokine receptor – HIV entry inhibitor Maraviroc complex

The CCR5 chemokine receptor acts as a co-receptor for HIV-1 viral entry. Here we report the 2.7 Å resolution crystal structure of human CCR5 bound to the marketed HIV drug Maraviroc. The structure reveals a ligand binding site that is distinct from the proposed major recognition sites for chemokines...

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Autors principals: Tan, Qiuxiang, Zhu, Ya, Li, Jian, Chen, Zhuxi, Han, Gye Won, Kufareva, Irina, Li, Tingting, Ma, Limin, Fenalti, Gustavo, Li, Jing, Zhang, Wenru, Xie, Xin, Yang, Huaiyu, Jiang, Hualiang, Cherezov, Vadim, Liu, Hong, Stevens, Raymond C., Zhao, Qiang, Wu, Beili
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3819204/
https://ncbi.nlm.nih.gov/pubmed/24030490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1241475
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