Structural basis for chemokine recognition by a G protein-coupled receptor and implications for receptor activation

Chemokines orchestrate cell migration for development, immune surveillance, and disease by binding to cell surface heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptors (GPCRs). The array of interactions between the nearly 50 chemokines and their 20 GPCR targets generates a...

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Udgivet i:Sci Signal
Main Authors: Ziarek, Joshua J., Kleist, Andrew B., London, Nir, Raveh, Barak, Montpas, Nicolas, Bonneterre, Julien, St-Onge, Geneviève, DiCosmo-Ponticello, Crystal J., Koplinski, Chad A., Roy, Ishan, Stephens, Bryan, Thelen, Sylvia, Veldkamp, Christopher T., Coffman, Frederick D., Cohen, Marion C., Dwinell, Michael B., Thelen, Marcus, Peterson, Francis C., Heveker, Nikolaus, Volkman, Brian F.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5648539/
https://ncbi.nlm.nih.gov/pubmed/28325822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aah5756
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