Structural basis for chemokine recognition by a G protein-coupled receptor and implications for receptor activation

Chemokines orchestrate cell migration for development, immune surveillance, and disease by binding to cell surface heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptors (GPCRs). The array of interactions between the nearly 50 chemokines and their 20 GPCR targets generates a...

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Publicado no:Sci Signal
Main Authors: Ziarek, Joshua J., Kleist, Andrew B., London, Nir, Raveh, Barak, Montpas, Nicolas, Bonneterre, Julien, St-Onge, Geneviève, DiCosmo-Ponticello, Crystal J., Koplinski, Chad A., Roy, Ishan, Stephens, Bryan, Thelen, Sylvia, Veldkamp, Christopher T., Coffman, Frederick D., Cohen, Marion C., Dwinell, Michael B., Thelen, Marcus, Peterson, Francis C., Heveker, Nikolaus, Volkman, Brian F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5648539/
https://ncbi.nlm.nih.gov/pubmed/28325822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aah5756
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