APP intracellular domain derived from amyloidogenic β- and γ-secretase cleavage regulates neprilysin expression

Alzheimer's disease (AD) is characterized by an accumulation of Amyloid-β (Aβ), released by sequential proteolytic processing of the amyloid precursor protein (APP) by β - and γ-secretase. Aβ peptides can aggregate, leading to toxic Aβ oligomers and amyloid plaque formation. Aβ accumulation is...

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Dades bibliogràfiques
Publicat a:Front Aging Neurosci
Autors principals: Grimm, Marcus O. W., Mett, Janine, Stahlmann, Christoph P., Grösgen, Sven, Haupenthal, Viola J., Blümel, Tamara, Hundsdörfer, Benjamin, Zimmer, Valerie C., Mylonas, Nadine T., Tanila, Heikki, Müller, Ulrike, Grimm, Heike S., Hartmann, Tobias
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2015
Matèries:
Neuroscience
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4443740/
https://ncbi.nlm.nih.gov/pubmed/26074811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2015.00077
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