APP intracellular domain derived from amyloidogenic β- and γ-secretase cleavage regulates neprilysin expression

Alzheimer's disease (AD) is characterized by an accumulation of Amyloid-β (Aβ), released by sequential proteolytic processing of the amyloid precursor protein (APP) by β - and γ-secretase. Aβ peptides can aggregate, leading to toxic Aβ oligomers and amyloid plaque formation. Aβ accumulation is...

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Detalhes bibliográficos
Publicado no:Front Aging Neurosci
Main Authors: Grimm, Marcus O. W., Mett, Janine, Stahlmann, Christoph P., Grösgen, Sven, Haupenthal, Viola J., Blümel, Tamara, Hundsdörfer, Benjamin, Zimmer, Valerie C., Mylonas, Nadine T., Tanila, Heikki, Müller, Ulrike, Grimm, Heike S., Hartmann, Tobias
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4443740/
https://ncbi.nlm.nih.gov/pubmed/26074811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2015.00077
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