Neprilysin and Aβ Clearance: Impact of the APP Intracellular Domain in NEP Regulation and Implications in Alzheimer’s Disease

One of the characteristic hallmarks of Alzheimer’s disease (AD) is an accumulation of amyloid β (Aβ) leading to plaque formation and toxic oligomeric Aβ complexes. Besides the de novo synthesis of Aβ caused by amyloidogenic processing of the amyloid precursor protein (APP), Aβ levels are also highly...

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Detalhes bibliográficos
Main Authors: Grimm, Marcus O. W., Mett, Janine, Stahlmann, Christoph P., Haupenthal, Viola J., Zimmer, Valerie C., Hartmann, Tobias
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2013
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3870290/
https://ncbi.nlm.nih.gov/pubmed/24391587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2013.00098
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