Upregulation of PGC-1α expression by Alzheimer’s disease-associated pathway: presenilin 1/amyloid precursor protein (APP)/intracellular domain of APP

Cleavage of amyloid precursor protein (APP) by β- and γ-secretase generates amyloid-β (Aβ) and APP intracellular domain (AICD) peptides. Presenilin (PS) 1 or 2 is the catalytic component of the γ-secretase complex. Mitochondrial dysfunction is an established phenomenon in Alzheimer’s disease (AD), b...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Robinson, Ari, Grösgen, Sven, Mett, Janine, Zimmer, Valerie C, Haupenthal, Viola J, Hundsdörfer, Benjamin, P Stahlmann, Christoph, Slobodskoy, Yulia, Müller, Ulrike C, Hartmann, Tobias, Stein, Reuven, Grimm, Marcus O W
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4331788/
https://ncbi.nlm.nih.gov/pubmed/24304563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12183
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