Neprilysin and Aβ Clearance: Impact of the APP Intracellular Domain in NEP Regulation and Implications in Alzheimer’s Disease

One of the characteristic hallmarks of Alzheimer’s disease (AD) is an accumulation of amyloid β (Aβ) leading to plaque formation and toxic oligomeric Aβ complexes. Besides the de novo synthesis of Aβ caused by amyloidogenic processing of the amyloid precursor protein (APP), Aβ levels are also highly...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Grimm, Marcus O. W., Mett, Janine, Stahlmann, Christoph P., Haupenthal, Viola J., Zimmer, Valerie C., Hartmann, Tobias
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2013
Aiheet:
Neuroscience
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3870290/
https://ncbi.nlm.nih.gov/pubmed/24391587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2013.00098
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