APP intracellular domain derived from amyloidogenic β- and γ-secretase cleavage regulates neprilysin expression

Alzheimer's disease (AD) is characterized by an accumulation of Amyloid-β (Aβ), released by sequential proteolytic processing of the amyloid precursor protein (APP) by β - and γ-secretase. Aβ peptides can aggregate, leading to toxic Aβ oligomers and amyloid plaque formation. Aβ accumulation is...

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Enregistré dans:
Détails bibliographiques
Publié dans:Front Aging Neurosci
Auteurs principaux: Grimm, Marcus O. W., Mett, Janine, Stahlmann, Christoph P., Grösgen, Sven, Haupenthal, Viola J., Blümel, Tamara, Hundsdörfer, Benjamin, Zimmer, Valerie C., Mylonas, Nadine T., Tanila, Heikki, Müller, Ulrike, Grimm, Heike S., Hartmann, Tobias
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2015
Sujets:
Neuroscience
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4443740/
https://ncbi.nlm.nih.gov/pubmed/26074811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2015.00077
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