DNA Vaccine Molecular Adjuvants SP-D-BAFF and SP-D-APRIL Enhance Anti-gp120 Immune Response and Increase HIV-1 Neutralizing Antibody Titers

Broadly neutralizing antibodies (bNAbs) specific for conserved epitopes on the HIV-1 envelope (Env) are believed to be essential for protection against multiple HIV-1 clades. However, vaccines capable of stimulating the production of bNAbs remain a major challenge. Given that polyreactivity and auto...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Gupta, Sachin, Clark, Emily S., Termini, James M., Boucher, Justin, Kanagavelu, Saravana, LeBranche, Celia C., Abraham, Sakhi, Montefiori, David C., Khan, Wasif N., Stone, Geoffrey W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4442371/
https://ncbi.nlm.nih.gov/pubmed/25631080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02904-14
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