HIV-1 Adenoviral Vector Vaccines Expressing Multi-Trimeric BAFF and 4-1BBL Enhance T Cell Mediated Anti-Viral Immunity

Adenoviral vectored vaccines have shown considerable promise but could be improved by molecular adjuvants. Ligands in the TNF superfamily (TNFSF) are potential adjuvants for adenoviral vector (Ad5) vaccines based on their central role in adaptive immunity. Many TNFSF ligands require aggregation beyo...

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Main Authors: Kanagavelu, Saravana, Termini, James M., Gupta, Sachin, Raffa, Francesca N., Fuller, Katherine A., Rivas, Yaelis, Philip, Sakhi, Kornbluth, Richard S., Stone, Geoffrey W.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2014
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3938597/
https://ncbi.nlm.nih.gov/pubmed/24587225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090100
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