HIV-1 Adenoviral Vector Vaccines Expressing Multi-Trimeric BAFF and 4-1BBL Enhance T Cell Mediated Anti-Viral Immunity

Adenoviral vectored vaccines have shown considerable promise but could be improved by molecular adjuvants. Ligands in the TNF superfamily (TNFSF) are potential adjuvants for adenoviral vector (Ad5) vaccines based on their central role in adaptive immunity. Many TNFSF ligands require aggregation beyo...

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Main Authors: Kanagavelu, Saravana, Termini, James M., Gupta, Sachin, Raffa, Francesca N., Fuller, Katherine A., Rivas, Yaelis, Philip, Sakhi, Kornbluth, Richard S., Stone, Geoffrey W.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3938597/
https://ncbi.nlm.nih.gov/pubmed/24587225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090100
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