The Heme Transport Capacity of LHR1 Determines the Extent of Virulence in Leishmania amazonensis

Leishmania spp. are trypanosomatid parasites that replicate intracellularly in macrophages, causing serious human morbidity and mortality throughout the world. Trypanosomatid protozoa cannot synthesize heme, so must acquire this essential cofactor from their environment. Earlier studies identified L...

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Опубликовано в: :PLoS Negl Trop Dis
Главные авторы: Renberg, Rebecca L., Yuan, Xiaojing, Samuel, Tamika K., Miguel, Danilo C., Hamza, Iqbal, Andrews, Norma W., Flannery, Andrew R.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2015
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441390/
https://ncbi.nlm.nih.gov/pubmed/26001191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0003804
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