Structural Features Facilitating Tumor Cell Targeting and Internalization by Bleomycin and Its Disaccharide

[Image: see text] We have shown previously that the bleomycin (BLM) carbohydrate moiety can recapitulate the tumor cell targeting effects of the entire BLM molecule, that BLM itself is modular in nature consisting of a DNA-cleaving aglycone which is delivered selectively to the interior of tumor cel...

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Udgivet i:Biochemistry
Main Authors: Yu, Zhiqiang, Paul, Rakesh, Bhattacharya, Chandrabali, Bozeman, Trevor C., Rishel, Michael J., Hecht, Sidney M.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2015
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4440614/
https://ncbi.nlm.nih.gov/pubmed/25905565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00277
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