The Disaccharide Moiety of Bleomycin Facilitates Uptake by Cancer Cells

[Image: see text] The disaccharide moiety is responsible for the tumor cell targeting properties of bleomycin (BLM). While the aglycon (deglycobleomycin) mediates DNA cleavage in much the same fashion as bleomycin, it exhibits diminished cytotoxicity in comparison to BLM. These findings suggested th...

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Main Authors: Schroeder, Benjamin R., Ghare, M. Imran, Bhattacharya, Chandrabali, Paul, Rakesh, Yu, Zhiqiang, Zaleski, Paul A., Bozeman, Trevor C., Rishel, Michael J., Hecht, Sidney M.
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2014
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183664/
https://ncbi.nlm.nih.gov/pubmed/25184545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja507255g
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