The Disaccharide Moiety of Bleomycin Facilitates Uptake by Cancer Cells

[Image: see text] The disaccharide moiety is responsible for the tumor cell targeting properties of bleomycin (BLM). While the aglycon (deglycobleomycin) mediates DNA cleavage in much the same fashion as bleomycin, it exhibits diminished cytotoxicity in comparison to BLM. These findings suggested th...

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Bibliografski detalji
Glavni autori: Schroeder, Benjamin R., Ghare, M. Imran, Bhattacharya, Chandrabali, Paul, Rakesh, Yu, Zhiqiang, Zaleski, Paul A., Bozeman, Trevor C., Rishel, Michael J., Hecht, Sidney M.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2014
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183664/
https://ncbi.nlm.nih.gov/pubmed/25184545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja507255g
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