Llwytho...

New developments for the design, synthesis and biological evaluation of potent SARS-CoV 3CL(pro) inhibitors

A series of trifluoromethyl, benzothiazolyl or thiazolyl ketone-containing peptidic compounds as SARS-CoV 3CL protease inhibitors were developed and their potency was evaluated by in vitro protease inhibitory assays. Three candidates had encouraging results for the development of new anti-SARS compo...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Bioorg Med Chem Lett
Prif Awduron: Regnier, Thomas, Sarma, Diganta, Hidaka, Koushi, Bacha, Usman, Freire, Ernesto, Hayashi, Yoshio, Kiso, Yoshiaki
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier Ltd. 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4436079/
https://ncbi.nlm.nih.gov/pubmed/19362479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.03.118
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