Overcoming the Cystic Fibrosis Sputum Barrier to Leading Adeno-associated Virus Gene Therapy Vectors

Gene therapy has not yet improved cystic fibrosis (CF) patient lung function in human trials, despite promising preclinical studies. In the human CF lung, inhaled gene vectors must penetrate the viscoelastic secretions coating the airways to reach target cells in the underlying epithelium. We invest...

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Publicat a:Mol Ther
Autors principals: Schuster, Benjamin S, Kim, Anthony J, Kays, Joshua C, Kanzawa, Mia M, Guggino, William B, Boyle, Michael P, Rowe, Steven M, Muzyczka, Nicholas, Suk, Jung Soo, Hanes, Justin
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4435598/
https://ncbi.nlm.nih.gov/pubmed/24869933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.89
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