Overcoming the Cystic Fibrosis Sputum Barrier to Leading Adeno-associated Virus Gene Therapy Vectors

Gene therapy has not yet improved cystic fibrosis (CF) patient lung function in human trials, despite promising preclinical studies. In the human CF lung, inhaled gene vectors must penetrate the viscoelastic secretions coating the airways to reach target cells in the underlying epithelium. We invest...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Schuster, Benjamin S, Kim, Anthony J, Kays, Joshua C, Kanzawa, Mia M, Guggino, William B, Boyle, Michael P, Rowe, Steven M, Muzyczka, Nicholas, Suk, Jung Soo, Hanes, Justin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4435598/
https://ncbi.nlm.nih.gov/pubmed/24869933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.89
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