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Common Gene Therapy Viral Vectors Do Not Efficiently Penetrate Sputum from Cystic Fibrosis Patients

Norwalk virus and human papilloma virus, two viruses that infect humans at mucosal surfaces, have been found capable of rapidly penetrating human mucus secretions. Viral vectors for gene therapy of Cystic Fibrosis (CF) must similarly penetrate purulent lung airway mucus (sputum) to deliver DNA to ai...

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Hlavní autoři: Hida, Kaoru, Lai, Samuel K., Suk, Jung Soo, Won, Sang Y., Boyle, Michael P., Hanes, Justin
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103503/
https://ncbi.nlm.nih.gov/pubmed/21637751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019919
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