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The penetration of fresh undiluted sputum expectorated by cystic fibrosis patients by non-adhesive polymer nanoparticles

Highly viscoelastic and adhesive sputum has precluded efficient nanoparticle-based drug and gene delivery to the lungs of patients with cystic fibrosis (CF). We sought to determine whether nanoparticles coated with non-mucoadhesive polymers could penetrate CF sputum, and to use these “muco-inert par...

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Bibliografski detalji
Glavni autori: Suk, Jung Soo, Lai, Samuel K., Wang, Ying-Ying, Ensign, Laura M., Zeitlin, Pamela L., Boyle, Michael P., Hanes, Justin
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2661768/
https://ncbi.nlm.nih.gov/pubmed/19176245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2008.12.076
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