N-acetylcysteine Enhances Cystic Fibrosis Sputum Penetration and Airway Gene Transfer by Highly Compacted DNA Nanoparticles

For effective airway gene therapy of cystic fibrosis (CF), inhaled gene carriers must first penetrate the hyperviscoelastic sputum covering the epithelium. Whether clinically studied gene carriers can penetrate CF sputum remains unknown. Here, we measured the diffusion of a clinically tested nonvira...

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Detalhes bibliográficos
Main Authors: Suk, Jung Soo, Boylan, Nicholas J, Trehan, Kanika, Tang, Benjamin C, Schneider, Craig S, Lin, Jung-Ming G, Boyle, Michael P, Zeitlin, Pamela L, Lai, Samuel K, Cooper, Mark J, Hanes, Justin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3222526/
https://ncbi.nlm.nih.gov/pubmed/21829177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.160
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