N-acetylcysteine Enhances Cystic Fibrosis Sputum Penetration and Airway Gene Transfer by Highly Compacted DNA Nanoparticles

For effective airway gene therapy of cystic fibrosis (CF), inhaled gene carriers must first penetrate the hyperviscoelastic sputum covering the epithelium. Whether clinically studied gene carriers can penetrate CF sputum remains unknown. Here, we measured the diffusion of a clinically tested nonvira...

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Hlavní autoři: Suk, Jung Soo, Boylan, Nicholas J, Trehan, Kanika, Tang, Benjamin C, Schneider, Craig S, Lin, Jung-Ming G, Boyle, Michael P, Zeitlin, Pamela L, Lai, Samuel K, Cooper, Mark J, Hanes, Justin
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2011
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3222526/
https://ncbi.nlm.nih.gov/pubmed/21829177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.160
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