N-acetylcysteine Enhances Cystic Fibrosis Sputum Penetration and Airway Gene Transfer by Highly Compacted DNA Nanoparticles

For effective airway gene therapy of cystic fibrosis (CF), inhaled gene carriers must first penetrate the hyperviscoelastic sputum covering the epithelium. Whether clinically studied gene carriers can penetrate CF sputum remains unknown. Here, we measured the diffusion of a clinically tested nonvira...

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Bibliografiske detaljer
Main Authors: Suk, Jung Soo, Boylan, Nicholas J, Trehan, Kanika, Tang, Benjamin C, Schneider, Craig S, Lin, Jung-Ming G, Boyle, Michael P, Zeitlin, Pamela L, Lai, Samuel K, Cooper, Mark J, Hanes, Justin
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3222526/
https://ncbi.nlm.nih.gov/pubmed/21829177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.160
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