Use of the CRISPR/Cas9 System to Produce Genetically Engineered Pigs from In Vitro-Derived Oocytes and Embryos

Targeted modification of the pig genome can be challenging. Recent applications of the CRISPR/Cas9 system hold promise for improving the efficacy of genome editing. When a designed CRISPR/Cas9 system targeting CD163 or CD1D was introduced into somatic cells, it was highly efficient in inducing mutat...

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Veröffentlicht in:Biol Reprod
Hauptverfasser: Whitworth, Kristin M., Lee, Kiho, Benne, Joshua A., Beaton, Benjamin P., Spate, Lee D., Murphy, Stephanie L., Samuel, Melissa S., Mao, Jiude, O'Gorman, Chad, Walters, Eric M., Murphy, Clifton N., Driver, John, Mileham, Alan, McLaren, David, Wells, Kevin D., Prather, Randall S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for the Study of Reproduction, Inc. 2014
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4435063/
https://ncbi.nlm.nih.gov/pubmed/25100712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1095/biolreprod.114.121723
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