Zygote injection of CRISPR/Cas9 RNA successfully modifies the target gene without delaying blastocyst development or altering the sex ratio in pigs

The CRISPR/Cas9 genome editing tool has increased the efficiency of creating genetically modified pigs for use as biomedical or agricultural models. The objectives were to determine if DNA editing resulted in a delay in development to the blastocyst stage or in a skewing of the sex ratio. Six DNA te...

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Detalhes bibliográficos
Publicado no:Transgenic Res
Main Authors: Whitworth, Kristin M., Benne, Joshua A., Spate, Lee D., Murphy, Stephanie L., Samuel, Melissa S., Murphy, Clifton N., Richt, Jürgen A., Walters, Eric, Prather, Randall S., Wells, Kevin D.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2016
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5247313/
https://ncbi.nlm.nih.gov/pubmed/27744533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11248-016-9989-6
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