Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor

The α7 nicotinic acetylcholine receptor (nAChR) belongs to the family of pentameric ligand-gated ion channels and is involved in fast synaptic signaling. In this study, we take advantage of a recently identified chimera of the extracellular domain of the native α7 nicotinic acetylcholine receptor an...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Spurny, Radovan, Debaveye, Sarah, Farinha, Ana, Veys, Ken, Vos, Ann M., Gossas, Thomas, Atack, John, Bertrand, Sonia, Bertrand, Daniel, Danielson, U. Helena, Tresadern, Gary, Ulens, Chris
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2015
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4434711/
https://ncbi.nlm.nih.gov/pubmed/25918415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1418289112
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