Allosteric binding site in a Cys-loop receptor ligand-binding domain unveiled in the crystal structure of ELIC in complex with chlorpromazine

Pentameric ligand-gated ion channels or Cys-loop receptors are responsible for fast inhibitory or excitatory synaptic transmission. The antipsychotic compound chlorpromazine is a widely used tool to probe the ion channel pore of the nicotinic acetylcholine receptor, which is a prototypical Cys-loop...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Nys, Mieke, Wijckmans, Eveline, Farinha, Ana, Yoluk, Özge, Andersson, Magnus, Brams, Marijke, Spurny, Radovan, Peigneur, Steve, Tytgat, Jan, Lindahl, Erik, Ulens, Chris
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087063/
https://ncbi.nlm.nih.gov/pubmed/27791038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1603101113
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