Allosteric binding site in a Cys-loop receptor ligand-binding domain unveiled in the crystal structure of ELIC in complex with chlorpromazine

Pentameric ligand-gated ion channels or Cys-loop receptors are responsible for fast inhibitory or excitatory synaptic transmission. The antipsychotic compound chlorpromazine is a widely used tool to probe the ion channel pore of the nicotinic acetylcholine receptor, which is a prototypical Cys-loop...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Nys, Mieke, Wijckmans, Eveline, Farinha, Ana, Yoluk, Özge, Andersson, Magnus, Brams, Marijke, Spurny, Radovan, Peigneur, Steve, Tytgat, Jan, Lindahl, Erik, Ulens, Chris
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2016
Aiheet:
PNAS Plus
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087063/
https://ncbi.nlm.nih.gov/pubmed/27791038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1603101113
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia