Structure of the SthK Carboxy-Terminal Region Reveals a Gating Mechanism for Cyclic Nucleotide-Modulated Ion Channels

Cyclic nucleotide-sensitive ion channels are molecular pores that open in response to cAMP or cGMP, which are universal second messengers. Binding of a cyclic nucleotide to the carboxyterminal cyclic nucleotide binding domain (CNBD) of these channels is thought to cause a conformational change that...

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Udgivet i:PLoS One
Main Authors: Kesters, Divya, Brams, Marijke, Nys, Mieke, Wijckmans, Eveline, Spurny, Radovan, Voets, Thomas, Tytgat, Jan, Kusch, Jana, Ulens, Chris
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4308110/
https://ncbi.nlm.nih.gov/pubmed/25625648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116369
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