An allosteric binding site of the α7 nicotinic acetylcholine receptor revealed in a humanized acetylcholine-binding protein

Nicotinic acetylcholine receptors (nAChRs) belong to the family of pentameric ligand-gated ion channels and mediate fast excitatory transmission in the central and peripheral nervous systems. Among the different existing receptor subtypes, the homomeric α7 nAChR has attracted considerable attention...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Delbart, Florian, Brams, Marijke, Gruss, Fabian, Noppen, Sam, Peigneur, Steve, Boland, Sandro, Chaltin, Patrick, Brandao-Neto, Jose, von Delft, Frank, Touw, Wouter G., Joosten, Robbie P., Liekens, Sandra, Tytgat, Jan, Ulens, Chris
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5818190/
https://ncbi.nlm.nih.gov/pubmed/29237730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.815316
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