An Unprecedented NADPH Domain Conformation in Lysine Monooxygenase NbtG Provides Insights into Uncoupling of Oxygen Consumption from Substrate Hydroxylation

N-Hydroxylating monooxygenases are involved in the biosynthesis of iron-chelating hydroxamate-containing siderophores that play a role in microbial virulence. These flavoenzymes catalyze the NADPH- and oxygen-dependent hydroxylation of amines such as those found on the side chains of lysine and orni...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Binda, Claudia, Robinson, Reeder M., Martin del Campo, Julia S., Keul, Nicholas D., Rodriguez, Pedro J., Robinson, Howard H., Mattevi, Andrea, Sobrado, Pablo
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432286/
https://ncbi.nlm.nih.gov/pubmed/25802330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.629485
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