The Structure of the Antibiotic Deactivating, N-hydroxylating Rifampicin Monooxygenase

Rifampicin monooxygenase (RIFMO) catalyzes the N-hydroxylation of the natural product antibiotic rifampicin (RIF) to 2′-N-hydroxy-4-oxo-rifampicin, a metabolite with much lower antimicrobial activity. RIFMO shares moderate sequence similarity with well characterized flavoprotein monooxygenases, but...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Liu, Li-Kai, Abdelwahab, Heba, Martin Del Campo, Julia S., Mehra-Chaudhary, Ritcha, Sobrado, Pablo, Tanner, John J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2016
Onderwerpen:
Protein Structure and Folding
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5076826/
https://ncbi.nlm.nih.gov/pubmed/27557658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.745315
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