The Legionella pneumophila GTPase Activating Protein LepB Accelerates Rab1 Deactivation by a Non-canonical Hydrolytic Mechanism

GTPase activating proteins (GAPs) from pathogenic bacteria and eukaryotic host organisms deactivate Rab GTPases by supplying catalytic arginine and glutamine fingers in trans and utilizing the cis-glutamine in the DXXGQ motif of the GTPase for binding rather than catalysis. Here, we report the trans...

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Autors principals: Mishra, Ashwini K., Del Campo, Claudia M., Collins, Robert E., Roy, Craig R., Lambright, David G.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Protein Structure and Folding
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3745345/
https://ncbi.nlm.nih.gov/pubmed/23821544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.470625
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