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Acetylation Stimulates the Epithelial Sodium Channel by Reducing Its Ubiquitination and Degradation

The epithelial Na(+) channel (ENaC) functions as a pathway for Na(+) absorption in the kidney and lung, where it is crucial for Na(+) homeostasis and blood pressure regulation. ENaC is regulated in part through signaling pathways that control the ubiquitination state of ENaC lysines. A defect in ubi...

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Vydáno v:J Biol Chem
Hlavní autoři: Butler, Phillip L., Staruschenko, Alexander, Snyder, Peter M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432271/
https://ncbi.nlm.nih.gov/pubmed/25787079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.635540
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