The Lhs1/GRP170 Chaperones Facilitate the Endoplasmic Reticulum-associated Degradation of the Epithelial Sodium Channel

The epithelial sodium channel, ENaC, plays a critical role in maintaining salt and water homeostasis, and not surprisingly defects in ENaC function are associated with disease. Like many other membrane-spanning proteins, this trimeric protein complex folds and assembles inefficiently in the endoplas...

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Autores principales: Buck, Teresa M., Plavchak, Lindsay, Roy, Ankita, Donnelly, Bridget F., Kashlan, Ossama B., Kleyman, Thomas R., Subramanya, Arohan R., Brodsky, Jeffrey L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Protein Synthesis and Degradation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3689978/
https://ncbi.nlm.nih.gov/pubmed/23645669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.469882
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