Hsp70 and Hsp90 Multichaperone Complexes Sequentially Regulate Thiazide-sensitive Cotransporter Endoplasmic Reticulum-associated Degradation and Biogenesis

The thiazide-sensitive NaCl cotransporter (NCC) is the primary mediator of salt reabsorption in the distal convoluted tubule and is a key determinant of the blood pressure set point. Given its complex topology, NCC is inefficiently processed and prone to endoplasmic reticulum (ER)-associated degrada...

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Bibliografiska uppgifter
Huvudupphovsmän: Donnelly, Bridget F., Needham, Patrick G., Snyder, Avin C., Roy, Ankita, Khadem, Shaheen, Brodsky, Jeffrey L., Subramanya, Arohan R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2013
Ämnen:
Membrane Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3642353/
https://ncbi.nlm.nih.gov/pubmed/23482560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.455394
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