WNK4 Diverts the Thiazide-sensitive NaCl Cotransporter to the Lysosome and Stimulates AP-3 Interaction

With-no-lysine kinase 4 (WNK4) inhibits electroneutral sodium chloride reabsorption by attenuating the cell surface expression of the thiazide-sensitive NaCl cotransporter (NCC). The underlying mechanism for this effect remains poorly understood. Here, we explore how WNK4 affects the trafficking of...

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Detalhes bibliográficos
Main Authors: Subramanya, Arohan R., Liu, Jie, Ellison, David H., Wade, James B., Welling, Paul A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Membrane Transport, Structure, Function, and Biogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709348/
https://ncbi.nlm.nih.gov/pubmed/19401467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.008185
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