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WNK kinases regulate thiazide-sensitive Na-Cl cotransport

Pseudohypoaldosteronism type II (PHAII) is an autosomal dominant disorder of hyperkalemia and hypertension. Mutations in two members of the WNK kinase family, WNK1 and WNK4, cause the disease. WNK1 mutations are believed to increase WNK1 expression; the effect of WNK4 mutations remains unknown. The...

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Détails bibliographiques
Auteurs principaux: Yang, Chao-Ling, Angell, Jordan, Mitchell, Rose, Ellison, David H.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2003
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC152590/
https://ncbi.nlm.nih.gov/pubmed/12671053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200317443
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