The small GTPase Arl8b regulates assembly of the mammalian HOPS complex on lysosomes

The homotypic fusion and protein sorting (HOPS) complex is a multi-subunit complex conserved from yeast to mammals that regulates late endosome and lysosome fusion. However, little is known about how the HOPS complex is recruited to lysosomes in mammalian cells. Here, we report that the small GTPase...

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Bibliographic Details
Published in:J Cell Sci
Main Authors: Khatter, Divya, Raina, Vivek B., Dwivedi, Devashish, Sindhwani, Aastha, Bahl, Surbhi, Sharma, Mahak
Format: Artigo
Language:Inglês
Published: The Company of Biologists 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432227/
https://ncbi.nlm.nih.gov/pubmed/25908847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.162651
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