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The Rab7 effector PLEKHM1 binds Arl8b to promote cargo traffic to lysosomes

Endocytic, autophagic, and phagocytic vesicles move on microtubule tracks to fuse with lysosomes. Small GTPases, such as Rab7 and Arl8b, recruit their downstream effectors to mediate this transport and fusion. However, the potential cross talk between these two GTPases is unclear. Here, we show that...

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Bibliografiske detaljer
Udgivet i:J Cell Biol
Main Authors: Marwaha, Rituraj, Arya, Subhash B., Jagga, Divya, Kaur, Harmeet, Tuli, Amit, Sharma, Mahak
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5379943/
https://ncbi.nlm.nih.gov/pubmed/28325809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201607085
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