Lysosomal Trafficking, Antigen Presentation, and Microbial Killing Are Controlled by the Arf-like GTPase Arl8b

Antigen presentation and microbial killing are critical arms of host defense that depend upon cargo trafficking into lysosomes. Yet, the molecular regulators of traffic into lysosomes are only partly understood. Here, using a lysosome-dependent immunological screen of a trafficking shRNA library, we...

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Detalhes bibliográficos
Main Authors: Garg, Salil, Sharma, Mahak, Ung, Cindy, Tuli, Amit, Barral, Duarte C., Hava, David L., Veerapen, Natacha, Besra, Gurdyal S., Hacohen, Nir, Brenner, Michael B.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3584282/
https://ncbi.nlm.nih.gov/pubmed/21802320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2011.06.009
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