Clearance of persistent hepatitis C virus infection using a claudin-1-targeting monoclonal antibody

Hepatitis C virus (HCV) infection is a leading cause of liver cirrhosis and cancer(1). Cell entry of HCV(2) and other pathogens(3-5) is mediated by tight junction (TJ) proteins, but successful therapeutic targeting of TJ proteins has not been reported yet. Using a human liver-chimeric mouse model(6)...

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Publicado no:Nat Biotechnol
Main Authors: Mailly, Laurent, Xiao, Fei, Lupberger, Joachim, Wilson, Garrick K., Aubert, Philippe, Duong, François H. T., Calabrese, Diego, Leboeuf, Céline, Fofana, Isabel, Thumann, Christine, Bandiera, Simonetta, Lütgehetmann, Marc, Volz, Tassilo, Davis, Christopher, Harris, Helen J., Mee, Christopher J., Girardi, Erika, Chane-Woon-Ming, Béatrice, Ericsson, Maria, Fletcher, Nicola, Bartenschlager, Ralf, Pessaux, Patrick, Vercauteren, Koen, Meuleman, Philip, Villa, Pascal, Kaderali, Lars, Pfeffer, Sébastien, Heim, Markus H., Neunlist, Michel, Zeisel, Mirjam B., Dandri, Maura, McKeating, Jane A., Robinet, Eric, Baumert, Thomas F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4430301/
https://ncbi.nlm.nih.gov/pubmed/25798937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3179
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