Clearance of persistent hepatitis C virus infection using a claudin-1-targeting monoclonal antibody

Hepatitis C virus (HCV) infection is a leading cause of liver cirrhosis and cancer(1). Cell entry of HCV(2) and other pathogens(3-5) is mediated by tight junction (TJ) proteins, but successful therapeutic targeting of TJ proteins has not been reported yet. Using a human liver-chimeric mouse model(6)...

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Библиографические подробности
Опубликовано в: :Nat Biotechnol
Главные авторы: Mailly, Laurent, Xiao, Fei, Lupberger, Joachim, Wilson, Garrick K., Aubert, Philippe, Duong, François H. T., Calabrese, Diego, Leboeuf, Céline, Fofana, Isabel, Thumann, Christine, Bandiera, Simonetta, Lütgehetmann, Marc, Volz, Tassilo, Davis, Christopher, Harris, Helen J., Mee, Christopher J., Girardi, Erika, Chane-Woon-Ming, Béatrice, Ericsson, Maria, Fletcher, Nicola, Bartenschlager, Ralf, Pessaux, Patrick, Vercauteren, Koen, Meuleman, Philip, Villa, Pascal, Kaderali, Lars, Pfeffer, Sébastien, Heim, Markus H., Neunlist, Michel, Zeisel, Mirjam B., Dandri, Maura, McKeating, Jane A., Robinet, Eric, Baumert, Thomas F.
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4430301/
https://ncbi.nlm.nih.gov/pubmed/25798937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3179
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