Clearance of persistent hepatitis C virus infection using a claudin-1-targeting monoclonal antibody

Hepatitis C virus (HCV) infection is a leading cause of liver cirrhosis and cancer(1). Cell entry of HCV(2) and other pathogens(3-5) is mediated by tight junction (TJ) proteins, but successful therapeutic targeting of TJ proteins has not been reported yet. Using a human liver-chimeric mouse model(6)...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Nat Biotechnol
Main Authors: Mailly, Laurent, Xiao, Fei, Lupberger, Joachim, Wilson, Garrick K., Aubert, Philippe, Duong, François H. T., Calabrese, Diego, Leboeuf, Céline, Fofana, Isabel, Thumann, Christine, Bandiera, Simonetta, Lütgehetmann, Marc, Volz, Tassilo, Davis, Christopher, Harris, Helen J., Mee, Christopher J., Girardi, Erika, Chane-Woon-Ming, Béatrice, Ericsson, Maria, Fletcher, Nicola, Bartenschlager, Ralf, Pessaux, Patrick, Vercauteren, Koen, Meuleman, Philip, Villa, Pascal, Kaderali, Lars, Pfeffer, Sébastien, Heim, Markus H., Neunlist, Michel, Zeisel, Mirjam B., Dandri, Maura, McKeating, Jane A., Robinet, Eric, Baumert, Thomas F.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2015
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4430301/
https://ncbi.nlm.nih.gov/pubmed/25798937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3179
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