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Discovering New Medicines Targeting Helicases: Challenges and Recent Progress

Helicases are ubiquitous motor proteins that separate and/or rearrange nucleic acid duplexes in reactions fueled by adenosine triphosphate (ATP) hydrolysis. Helicases encoded by bacteria, viruses, and human cells are widely studied targets for new antiviral, antibiotic, and anticancer drugs. This re...

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Detalhes bibliográficos
Publicado no:SLAS Discov
Main Authors: Shadrick, William R., Ndjomou, Jean, Kolli, Rajesh, Mukherjee, Sourav, Hanson, Alicia M., Frick, David N.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Laboratory Automation and Screening. Published by Elsevier Inc. 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4427233/
https://ncbi.nlm.nih.gov/pubmed/23536547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057113482586
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