Putting Tuberculosis (TB) To Rest: Transformation of the Sleep Aid, Ambien, and “Anagrams” Generated Potent Antituberculosis Agents

[Image: see text] Zolpidem (Ambien, 1) is an imidazo[1,2-a]pyridine-3-acetamide and an approved drug for the treatment of insomnia. As medicinal chemists enamored by how structure imparts biological function, we found it to have strikingly similar structure to the antitubercular imidazo[1,2-a]pyridi...

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Bibliografiska uppgifter
I publikationen:ACS Infect Dis
Huvudupphovsmän: Moraski, Garrett C., Miller, Patricia A., Bailey, Mai Ann, Ollinger, Juliane, Parish, Tanya, Boshoff, Helena I., Cho, Sanghyun, Anderson, Jeffery R., Mulugeta, Surafel, Franzblau, Scott G., Miller, Marvin J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2014
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4426345/
https://ncbi.nlm.nih.gov/pubmed/25984566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/id500008t
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