Putting Tuberculosis (TB) To Rest: Transformation of the Sleep Aid, Ambien, and “Anagrams” Generated Potent Antituberculosis Agents

[Image: see text] Zolpidem (Ambien, 1) is an imidazo[1,2-a]pyridine-3-acetamide and an approved drug for the treatment of insomnia. As medicinal chemists enamored by how structure imparts biological function, we found it to have strikingly similar structure to the antitubercular imidazo[1,2-a]pyridi...

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Detalhes bibliográficos
Publicado no:ACS Infect Dis
Main Authors: Moraski, Garrett C., Miller, Patricia A., Bailey, Mai Ann, Ollinger, Juliane, Parish, Tanya, Boshoff, Helena I., Cho, Sanghyun, Anderson, Jeffery R., Mulugeta, Surafel, Franzblau, Scott G., Miller, Marvin J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4426345/
https://ncbi.nlm.nih.gov/pubmed/25984566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/id500008t
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