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Advancement of Imidazo[1,2-a]pyridines with Improved Pharmacokinetics and nM Activity vs. Mycobacterium tuberculosis
[Image: see text] A set of 14 imidazo[1,2-a]pyridine-3-carboxamides was synthesized and screened against Mycobacterium tuberculosis H(37)Rv. The minimum inhibitory concentrations of 12 of these agents were ≤1 μM against replicating bacteria and 5 compounds (9, 12, 16, 17, and 18) had MIC values ≤0.0...
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| Hoofdauteurs: | , , , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Chemical Society
2013
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| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3733398/ https://ncbi.nlm.nih.gov/pubmed/23930153 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400088y |
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