Advancement of Imidazo[1,2-a]pyridines with Improved Pharmacokinetics and nM Activity vs. Mycobacterium tuberculosis

[Image: see text] A set of 14 imidazo[1,2-a]pyridine-3-carboxamides was synthesized and screened against Mycobacterium tuberculosis H(37)Rv. The minimum inhibitory concentrations of 12 of these agents were ≤1 μM against replicating bacteria and 5 compounds (9, 12, 16, 17, and 18) had MIC values ≤0.0...

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Detalhes bibliográficos
Main Authors: Moraski, Garrett C., Markley, Lowell D., Cramer, Jeffrey, Hipskind, Philip A., Boshoff, Helena, Bailey, Mai A., Alling, Torey, Ollinger, Juliane, Parish, Tanya, Miller, Marvin J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3733398/
https://ncbi.nlm.nih.gov/pubmed/23930153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400088y
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