Natural Killer Cell Sensing of Infected Cells Compensates for MyD88 Deficiency but Not IFN-I Activity in Resistance to Mouse Cytomegalovirus

In mice, plasmacytoid dendritic cells (pDC) and natural killer (NK) cells both contribute to resistance to systemic infections with herpes viruses including mouse Cytomegalovirus (MCMV). pDCs are the major source of type I IFN (IFN-I) during MCMV infection. This response requires pDC-intrinsic MyD88...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Cocita, Clément, Guiton, Rachel, Bessou, Gilles, Chasson, Lionel, Boyron, Marilyn, Crozat, Karine, Dalod, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4425567/
https://ncbi.nlm.nih.gov/pubmed/25954804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004897
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