Natural Killer Cell Sensing of Infected Cells Compensates for MyD88 Deficiency but Not IFN-I Activity in Resistance to Mouse Cytomegalovirus

In mice, plasmacytoid dendritic cells (pDC) and natural killer (NK) cells both contribute to resistance to systemic infections with herpes viruses including mouse Cytomegalovirus (MCMV). pDCs are the major source of type I IFN (IFN-I) during MCMV infection. This response requires pDC-intrinsic MyD88...

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Dettagli Bibliografici
Pubblicato in:PLoS Pathog
Autori principali: Cocita, Clément, Guiton, Rachel, Bessou, Gilles, Chasson, Lionel, Boyron, Marilyn, Crozat, Karine, Dalod, Marc
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4425567/
https://ncbi.nlm.nih.gov/pubmed/25954804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004897
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