Natural Killer Cell Sensing of Infected Cells Compensates for MyD88 Deficiency but Not IFN-I Activity in Resistance to Mouse Cytomegalovirus

In mice, plasmacytoid dendritic cells (pDC) and natural killer (NK) cells both contribute to resistance to systemic infections with herpes viruses including mouse Cytomegalovirus (MCMV). pDCs are the major source of type I IFN (IFN-I) during MCMV infection. This response requires pDC-intrinsic MyD88...

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Опубликовано в: :PLoS Pathog
Главные авторы: Cocita, Clément, Guiton, Rachel, Bessou, Gilles, Chasson, Lionel, Boyron, Marilyn, Crozat, Karine, Dalod, Marc
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2015
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4425567/
https://ncbi.nlm.nih.gov/pubmed/25954804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004897
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