Phosphorylation of Minichromosome Maintenance 3 (MCM3) by Checkpoint Kinase 1 (Chk1) Negatively Regulates DNA Replication and Checkpoint Activation

Mechanisms controlling DNA replication and replication checkpoint are critical for the maintenance of genome stability and the prevention or treatment of human cancers. Checkpoint kinase 1 (Chk1) is a key effector protein kinase that regulates the DNA damage response and replication checkpoint. The...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Han, Xiangzi, Mayca Pozo, Franklin, Wisotsky, Jacob N., Wang, Benlian, Jacobberger, James W., Zhang, Youwei
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
DNA and Chromosomes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4424366/
https://ncbi.nlm.nih.gov/pubmed/25809478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.621532
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