Conformational Change of Human Checkpoint Kinase 1 (Chk1) Induced by DNA Damage

Phosphorylation of Chk1 by ataxia telangiectasia-mutated and Rad3-related (ATR) is critical for checkpoint activation upon DNA damage. However, how phosphorylation activates Chk1 remains unclear. Many studies suggest a conformational change model of Chk1 activation in which phosphorylation shifts Ch...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Han, Xiangzi, Tang, Jinshan, Wang, Jingna, Ren, Feng, Zheng, Jinhua, Gragg, Megan, Kiser, Philip, Park, Paul S. H., Palczewski, Krzysztof, Yao, Xinsheng, Zhang, Youwei
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2016
Konular:
DNA and Chromosomes
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933214/
https://ncbi.nlm.nih.gov/pubmed/27129240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.713248
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